Paper Information

Title: 

THE EFFECT OF KETOCONAZOL CHRONIC PRESCRIPTION ON SPERMATOGENESIS INDEXES IN TESTIS TISSUE ON MICE

Type: POSTER
Author(s): KHAYAT NOURI M.H.*,SAFAVI S.E.,MIRZAEI A.,SEDIGH ETEGHAD S.
 
 *UNIVERSITY, TABRIZ BRANCH
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Ketoconazol "with a wide usage in treatment of fungal disease" is an important antifungal drug. This drug, in addition to being antifungal, has an inhibitory effect on steroid hormones which concludes sexual hormones & glucocorticoids. According to recent studies the usage of Ketoconazol causes to reduce the amount of testosterone in blood & different changes in testis tissue on laboratory animals.
Method: 100 male mice's are used in this study (10 groups and 10 mice's in each group). Different dose of Ketoconazol (12.5, 25, 50mg/kg) are used orally by the animals daily, during 1, 2, 3 mounts. As one group was normal (normal saline) & nine groups was drug consumer. The testis tissue was sampled after passing of above times and section providing, was stained by H & E. Then, in point of spermatogenesis indexes which include, tubular differentiation index (TDI), spermatogenism index (SI), and repopulation index (RI), were studied.
Results: According to the result in the first mount, RI, SI, TDI, had non significant changes (p>0.05) but the second & third mount's after drug usage, they had rather significant changes than the normal group (p<0.05). This reduction is related to drug dose and the considered reductions will be significant severely, by increasing of drug dose (p<0.01).There was the most spermatogenesis indexes reduction in the animals which concept 50mg/kg  during 3 mounts (p<0.01).
Discussion: Reduction of spermatogenesis and its index in mice testis is the result of ketoconazol chronic prescription. Probably this reduction amount of TDI, SI, and RI acted via the reducing of testosterone serum consistency. So Ketoconazol effect in spermatogenesis and unfertilization in human needs to more consideration.

 
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