Paper Information

Title: 

EFFECTS OF BISMUTH ON SOME PARAMETERS OF METABOLISM IN RAT

Type: POSTER
Author(s): BABAEI A.,MOSHTAGHI A.A.,SORBI P.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Colloidal bismuth salysilate and some of the other insoluble bismuth salts are effective drugs in treatment of ulcer of stomach and duodenum and also diarrhea. One of the bismuth effects is the effect on the gastrointestinal absorption of tetrasyc- line, calcium and specially Iran. Content of food, and decreasing the gastrointestinal absorption of these compounds. The reason for that is well known as chelating of bismuth with these compounds. Even though bismuth has medical uses, it is reported that have many side effects on patients with chronic gastrointestinal problems,causing psychological effects with usage of bismuth as reported in Australia  & France. These patients are suffering from dysfunctional muscle movement, depression, nervousness fallowing with some mental side effects. Tremors dysphasia, the aim of the study was to investigate the toxicity effects of bismuth. For this reason, during two short periods of 5 and 15 days, and two long periods of 30 and 60 days, different amounts of bismuth nitrate have injected in prêt mum to male rats and factors related to Iron metabolism were analyzed. The results obtained in this project show that the amount of ceruloplasmin between 12.98 and 19.7% and the amount of serum iron show the minimum decrease rather than the control group which is 10.9% and 27.4% and hemoglobin shows the minimum 19.27% and 6.8% decrease on the control group and the decrease of hematocrit of 14.65 and 19.7% and TIBC 5.09% and 16.3% show increase rather than control group, on the other hand, it shows the minimum decrease of serum copper in comparison with control group which is 10.45% and 27.45% and it relates to daily prescribed bismuth nitrate of 80 µmol/kg body weight, during 15days and 50 µmol/kg body weight during 30 days in order, rather than control group. The long term usage of bismuth compounds results in disturbance in Iran Metabolism and causes anemia.

 
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