Paper Information

Title:  INVOLVEMENT OF NITRIC OXIDE IN INCOTINE-INDUCED BEHAVIORAL SENSITIZATION IN MICE
Type: POSTER
Author(s): GHOSHOUNI H.*,SHIRAZI ASHRAF,SAHRAEI HEDAYAT
 
 *DEPTARTMENT OF PHYSIOLOGY AND BIOPHYSICS, CHEMICAL INJURIES RESEARCH CENTER
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Experiments have shown that repeated administration of nicotine may increase the responsibility to the drug so that the ineffective amounts of nicotine may produce several behaviors including behavioral sensitization. In the present study, the effects of L-arginine and L-NAME on the acquisition and expression of nicotine-induced behavioral sensitization in male N-MARI mice (20-25 g) were investigated.
Methods: Animals became sensitized to nicotine by daily injection of the drug (0.25 mg/kg for five consecutive days and 4 days rest). Ineffective dose of nicotine (0.1 mg/kg) produced a marked increase in animal’s activity in the nicotine-sensitized mice.
Results: Administration of L-arginine (5-50 mg/kg) before nicotine injection did not affect the nicotine-induced behavioral sensitization. Injection L-arginine (5-50 mgkg, i.p.) enhances the effects nicotine on animal’s activity. Administration of L-NAME (5-20 mg/kg, i.p.) reduced both the acquisition and expression of nicotine-induced behavioral sensitization.
Conclusion: It could be concluded that nitirc oxide may play a role in the acquisition and expression of nicotine-induced behavioral sensitization in mice.

 
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