Paper Information

Title: 

THE EFFECT OF INGESTION OF SHARK CARTILAGE ON THE GROWTH OF DMBA INDUCED MAMMARY TUMOR IN SPRAGUE DAWLEY RAT

Type: POSTER
Author(s): RAZMI N.,TABANDEH M.R.,KALALIAN MOGHADAM H.,BABAKHANI A.A.F.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: According to recent research, shark cartilage has been a popular complementary medicine intervention on the basis of this claim that sharks rarely get cancer. However early studies in experimental and clinical trial is equivocal.
Methods: Sixty female Sprague dawley rat were divided in two group (30 rat in each group) Pretumor establishment treatment (PRTE) and Post tumor Stablishment treatment (PSTE). Each group divided in two sub group control (n=15) and treatment (n=15). Tumor was induced by DMBA, 20mg/2ml corn oil Cartilage powder were prepared from neural cord of white snout shark from Persian Gulf. PRTE group, 30days after tumor induction treated with 10mg/day /rat shark cartilage for 30 days. PSTE group were treated as well as PRTE group but after palpable tumors were stablished. Animal weight gaining, tumor induction time, tumor number and size were recorded on induction and 30, 60, 120 and 200 days after induction.
Results: There was no significant difference in number and size of tumor between PRTE and PRTE Control 2 month after treatment (P<0.05) but this difference was significant between PSTE and PSTE control (P<0.05). Two month after traetment tumors significantly ragressed in PSTE group. Weight gaining in PSTE group was significantly more than other gruops at the end of study.
Conclusion: Mamary tumor in rat is regressed when 10mg/day/rat shark cartilage were administrated orally and weight gaining was better two month after treatment

 
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