Paper Information

Title: 

THE EFFECT OF CMF AND TAMOXIFEN TREATMENT ON SERUM AND TISSUE LEVELS OF TRACE ELEMENTS IN DMBA INDUCED MAMMARY TUMOR IN RATS

Type: POSTER
Author(s): RAZMI N.,TABANDEH M.R.,BAGHSHAINI H.*
 
 *DEPT. OF BIOCHEMISTRY, SCHOOL OF VETERINARY MEDICINE, SHIRAZ UNIVERSITY
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Abnormal serum and tissue trace element levels have been found in variety of malignancy In the present study we evaluate trace elements level changes after treatment with CMF and tamoxifen in a experimental mammary tumor model in rat.
Methods: Frothy female Sprague dawley rats, were divided in four groups including : 1- negative control (healthy rats without treatment), 2-positive control (DMBA induced mammary tumor without treatment), 3- DMBA induced mammary tumor , treated with tamoxifen 5mg/day) and 4- DMBA induced mammary tumor ,treated with CMF 150/30/150 mg/m2). Tumor was induced by DMBA, 20mg/2ml in corn oil Tumor development was examined by milk line palpation. After palpable tumors were stablished treatment was initiated for 60 days. After treatment tissue and serum samples were taken and Cu, Zn, Co, Mn, Se, Ca and Mg were determined by atomic absorbtion spectrophotometry.
Results: In tamoxifen treated group significant elevation of Mg and reduction of Ca were shown but CMF has opposite effect on Ca and no significant effect on Mg (P<0.05). Interestingly, the Cu/Zn ratio in both treated groups was lower than positive control group and Zn was significantly elevated in treated group (P<0.05) but Tamoxifen had better effect.
Conclusion: treatment with tamoxifen improved Zn/Cu level in rats with mammary tumor with significand elevation of Zn.

 
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