Paper Information

Title: 

STUDIES OF ACYCLOVIRSIDE EFFECTS ON DEVELOPING EMBRYOS OF BALB/C MICE STRAIN

Type: POSTER
Author(s): PARIVAR KAZEM,MOHSENI KOUCHESFAHANI HOMA,MOHAMMADZADEH ASL B.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Acyclovir is a drug which is used against herpes virus and it is administrated for treatment of cold catch injuries, hot spots of genital organs, zona, aids, chicken pox and some other viral infections. The local cream of acyclovir is prepared in %5 packages each gram of it containing 50mg of drug in a base of polyethylene glycol.
Methods: Acyclovir cream (%5) in days 7, 8 and 9 of gestation was applied around their mouth as experimental group1 and to the shared skin of other group as experimental group 2 twice a day in two hours intervals. Pregnant mice were sacrificed and dissected on day 15 of gestation and morphological and histological studies on the embryos and placenta were corried out. In addition in the case of non-pregnant mice the uteral borns and ovaries were processed for histological investigations.
Results: Histological analyses of the results showed significant decrease in embryogenesis and significant increase of abortion in experimental group1 compared with control group.
Conclusion: significant increase in the parameters of uterus diameter and thickness of endometrium were observed comparing with control group. According to our results, a pregnant individual should be very cautious about applying acyclovir during the first trimester of pregnancy.

 
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