Paper Information

Title: 

ANALGESIC ACTIVITY OF THE METHANOLIC EXTRACT AND TOTAL ALKALOIDS OF GLAUCIUM PAUCILOBUM

Type: POSTER
Author(s): MAHMOUDI M.*
 
 *DEPARTMENT OF PHARMACOLOGY, FACULTY OF MEDICINE, MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, SARI, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Background: The species of Glaucium have been used in Iranian herbal medicine as laxative, hypnotic, narcotic and antidiabetic agents and also in the treatment of dermatitis. The analgesic activity of the aerial parts of Glaucium paucilobum Freyn (Papaveraceae) (GP).
Materials and methods: GP a native plant of Iran, were studied using formalin, hot plate and writhing tests in rodents.
Results: The methanolic extract and total alkaloids of GP caused graded inhibition of both phases of formalin-induced pain. In hot plate test, the i.p. administration of GP extract at the doses of 50-90 mg/kg and total alkaloids at the dose of 10-60 mg/kg significantly raised the pain threshold at a observation time of  30 min in comparison with control (P<0.001). In the writhing test, the extract at doses of 30-90 mg/kg and total alkaloids at the doses of 10-60 mg/kg produced a significant decrease in the number of writhing in comparison with the control group (P<0.001). The methanolic extract and total alkaloids of GP at antinociceptive doses, did not affect motor coordination of animals when assessed in the rotarod model.
Conclusion: The results showed that analgesic activity of this plant may be related partly to the alkaloids.

 
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