Paper Information

Title: 

THE INTRAGASTRIC EFFECT OF AQUEOUS ELAEGNUS ANGUSTIFOLIA EXTRACT ON CARBACHOL-STIMULATED GASTRIC ACID SECRETION IN ANESTHETIZED RATS

Type: POSTER
Author(s): MANDIPOUR M.*,KAMALINEZHAD M.,GHODRATI M.,ELIASI A.
 
 *FACULTY OF PHARMACY, SHAHEED BEHESHTI UNIVERSITY OF MEDICAL SCIENCES
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: the antigastric ulcer effects of elaegnus angustifolia have been reported. In the present study we investigated intragastric effect of elaegnus angustifolia extract on carbachol_stimulated gastric acid secretion.
Methods: The aqueous elaegnus angustifolia extract was prepared from JOLFA (AZARBAIJAN). WISTAR rats were used in all experiments. Animals were deprived from food 24 hours before experiments. After anesthetizinga animals, a polyethylene tube was introduced into the stomach through esophagus and another one was ligated in pylorodeodenal junction. Intravenous infusion of carbachol (1µg/100gr/hr) was performed for 110 min and intragastric elaegnus angustifolia was administrated at the appropriate time and acid secretion was titrated with NaOH (0.01N) up to pH=7 every 10 min (without administrating elaegnus angustifolia).
Results: Intravenous infusion of carbachol induced marked increase in acid secretion with a peak response that started from 30 min to the end of experiments. Intragastric administration of extract at the maximum carbachol-induced gastric acid secretion (8±1mEq/10 min, at 30th min) inhibited stimulated acid secretion in a time dependent manner (1.8±0.4mEq/10 min, at 90th min). We did not observe any effect on stimulated acid secretion when the extract administrated at the beginning of carbachol infusion.
Conclusion: Our results showed that intragastric administration of elaegnus angustifolia significantly decreased stimulated gastric acid secretion while there was not observed any effect in physiological conditions. It seems that the extract will be activated at very low pH.

 
Keyword(s): 
 
Yearly Visit 17   tarjomyar
 
Latest on Blog
Enter SID Blog