Paper Information

Title: 

IRANIAN GREEN TEA EXTRACTS CREAM: AN EFFECTIVE AND QUALIFIED FORMULATION FOR WOUND HEALING

Type: POSTER
Author(s): MOGHBEL A.*,SALIMI A.,KALANTARI A.,RAHIMZADEH F.,AGHELI H.,NAZARI Z.
 
 *DEPT. OF PHARMACEUTICS, AHVAZ JUNDISHAPOUR UNIVERSITY OF MEDICAL SCIENCES, AHVAZ, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: The green tea extract containing polyphenols with powerful antioxidant and tannis could be a useful pharmaceutical product for the treatment or improvement of lesions.
Methods: The green tea leaves were dried at 40C using pan-frying method. The powdered green tea (100g, 5mesh) was obtained after lyophilization of the aqueous extract (1:1+10g glycerin) by a freeze-dryer. The presence and quantity of tannins (target active ingredient) were determined using Folin-Denis method. Two formulations of 5 and 10 percents of powdered green tea were prepared in a hydrophilic base (USP) with some other inactive ingredients as adjuncts. The physicochemical characteristics of the formulations were controlled base on the presence of tannis, as the most effective agent on wound healing.
Results: The amount of tannis was obtained 6.23±0.19mg/100mg of the extract. The formulation which contained 10% of green tea extract was not physically stable even 48 hours after production, while the 5% product showed a good stability performing all quality control tests. After 6 hrs of release experiment, 63.70±0.4 and 7.22±0.005 percent of tannin were released to receptor medium consisted of normal saline and hydro alcoholic solution (1:1), respectively. The kinetic pattern, up to 60% of release was followed by Higuchi's model (p<0.01).
Conclusions: The semisolid botanical formulation of green tea extract containing compounds which have healing properties could be a useful pharmaceutical of choice comparing chemical formulations, with less dermal adverse effects and toxicity.

 
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