Paper Information

Title:  IN VITRO ANTI-HELICOBACTER PYLORI ACTIVITY OF CUMIN (CUMINUM CYMINUM L.) METHANOL AND AQUEOUS EXTRACTS
Type: POSTER
Author(s): MOGHADAM MAHBOUBEH,KHAJEH KARAM ALDINI M.,RAMEZANI M.,NAKHAEI MOGHADAM M.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Cumin (C. cyminum) is a native plant of Iran and it is benefit for gastric problems in traditional medicine. In this study its activity against Helicobacter pylori (HP) was examined. HP infection is the most common gastrointestinal bacterial disease worldwide.
Methods: Percolated methanol and aqueous extracts of plant fruits were tested against 45 clinical isolates of HP. Growth inhibition was determined by the filter paper disc diffusion method on modified egg yolk emulsion agar (EYE agar) compared with amoxicillin. MIC was determined by agar dilution. The buthanol fraction of cumin was screened for saponins by formation of stable foam after precipitation of saponins.
Results: The effect of methanol extract (14.90±2.0mm) of C. cyminum was significantly) much than its aqueous extract (8.79±2.3mm). The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of methanol extract of C. cyminum was 691µg/ml. Methanol extract preserved its anti- Helicobacter pylori activity after autoclaving for 20min. Preliminary phytochemical screening of C. cyminum indicated the presence of saponins.
Conclusion: C. cyminum showed anti- Helicobacter pylori activity and it is suggested that a part of its antibacterial activity may concern to saponins. Since C. cyminum is a natural product and its consumption is tradition, research for fractionation and purification of its constituents is recommended.

 
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