Paper Information

Title: 

GASTROPROTECTIVE EFFECT OF ALHAGI CAMELORUM ON EXPERIMENTAL GASTRIC ULCER IN RATS

Type: POSTER
Author(s): MARD S.A.,NEYSI N.,GHARIB NASERI MOHAMMAD KAZEM
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Background:  Alhagi camelorum belongs to the family Leguminosae is used in Iranian folk medicine to treat gastric disturbances. The present study was undertaken to evaluate the Alhagi camelorum aqueous extract for anti-ulcer activity in rat.
Methods: male Wistar rats were pretreated with the Alhagi camelorum aqueous extract (150, 300 and 450 mg/kg, P.O.) before induction of gastric ulcer by water immersion restraint-stress (5 h, water immersion restraint stress at (20-22oC) or ethanol (100%; 1ml/200g of B.W, P.O.). Negative control animals received saline (0.5 ml/100 g of B.W) and positive control animals received ranitidine (60 mg/kg, P.O.).

Results: The Alhagi camelorum aqueous extract protected rats against water immersion restraint-stress and ethanol-induced ulcers in a dose-dependent manner. In water immersion restraint induced ulcerated rat, the AME increased pH and reduced gastric acid content. AME did not show any signs of toxicity and mortality up to 10g/kg, P.O. in mice.
Conclusion: The results suggest that Alhagi camelorum aqueous extract has significant mucosal protective and antisecretory effects.

 
Keyword(s): 
 
Yearly Visit 23   tarjomyar
 
Latest on Blog
Enter SID Blog