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Paper Information

Title: 

EVALUATION THE EFFECTS OF SUPEROVULATION WITH GONADOTROPHINS ON IMPLANTATION AND FETAL DEVELOPMENT IN MICE

Type: POSTER
Author(s): ZARBAKHSH S.*,HASHEMI TABAR MAHMOUD,JAVADNIA F.,MOHAMMADI M.
 
 *DEPARTMENT OF ANATOMY, SCHOOL OF MEDICINE, IRAN UNIVERSITY OF MEDICAL SCIENCE
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: The aim of this study was evaluation the effects of superovulation with gonadotrophins on implantation and fetal weights and development after blastocysts transfer in mice.
Methods: NMRI female mice 2-3 months old, were haphazardly divided into two groups control and experimental; and each group was divided into two groups donor and recipient. All of donors and experimental recipients were superovulated with PMSG and hCG. 5 and 10 obtained blastocysts were respectively transferred into left and right uterine horns of pseudopregnant recipients. All of recipients were killed on day 14 of pregnancy and were evaluated from the rate of implantation and fetal weights.
Results:
No statistically significant was observed in the grown fetal rate in superovulated recipients (6.1%) compared with control recipients (7.3%). The grown fetal rate in the left horn of uterine (13% in control recipients and 11.4% in superovulated recipients) was significantly higher than in the right horn (4.5% in control recipients and 3.5% in superovulated recipients). No statistically significant was observed in the rate of ungrown fetuses in superovulated recipients (10.4%) compared with control recipients (12.3%). No statistically significant was observed in the mean weight of fetuses obtained from superovulated recipients compared with that of fetuses obtained from control recipients.
Conclusion: No significantly effect was observed in the ovarian stimulation on implantation rate and fetal growth. The capacity of receptivity of uterine does not increase with add embryos.

 
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