Paper Information

Title: 

THE EFFECT OF HYDROXYCHLOROQUINE SULFATE ON CONCENTRATION OF LH,FSH AND TESTOSTERONE IN ADULT MALE RATS

Type: POSTER
Author(s): KHEZRI MOTLAGH S.*,SHARIATI M.,MOKHTARI M.,KHEZRI MOTLAGH R.
 
 *DEPARTMENT OF BIOLOGY, FACULTY OF SCIENCES, ISLAMIC AZAD UNIVERSITY, KAZEROON BRANCH, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: IL-1 and TNF are two major inflammatory cytokine which cause joint destruction in rheumatoid arthritis. Hydroxychloroquine sulfate is one of the disease- modifying antirheumatic drug which inhibiting IL-1 and TNF which help to cause tissue injury in chronic disease such as RA. In this research the effect of Hydroxychloroquine sulfate on spermatogenesis and concentration LH, FSH, testosterone in male rat were studied.
Methods: The animals used 40 adult male rats from wistar Strain were divided in to 4 groups of 8. The three experimental groups received 15, 30 and 60mg/ kg/ day doses for 28 days Hydroxychloroquine sulfate, via intraperitoneal injection and control group received distalled water. The blood samples were taken and the concentration of LH, FSH, and testosterone were measured by RIA.
Results: concentration of LH and FSH hormones did not show significant difference compared with the control group. While at maximum amount of the drug, testosterone showed a meaningful reduction at the level of p
£.05.
Conclusion: Hydroxychloroquine sulfate via reducing the secretion of ACTH or via induce in secration prolactin that can reduced the testosterone secretion. It looks the number of setoli cell in group 3 compared with control group showed decrease. Probably, reducing testosterone causes reduction in setoli cell.

 
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