Paper Information

Title: 

OSMOTIC FRAGILITY OF RED BLOOD CELLS IN HYPERTHYROID RATS

Type: POSTER
Author(s): HABIBI G.,GHASEMI A.,PANAHIRAD SH.,FARAJI F.,ZAHEDIASL S.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Hyperthyroidism is associated with anemia. Since thyroid hormones by acting on Na+/K+-ATPase activity and numbers, and also lipid composition of the membrane can alter the fragility of the red cells. In this study, the osmotic fragility of the red cells in hyperthyroid rats has been compared with control.
Materials and method: Forty eight male Wistar rats (body weight, 221±4g) were divided in 4 groups. Group I consumed L-thyroxin (12mg/L in drinking water) for 30 days, group II was control for the group I, group III consumed L-thyroxin for 60 days and group IV was the control group for the group III. At the end of the intervention period, hormonal and biochemical measurements were done in blood samples. To assess the osmotic fragility, red blood cells (RBC) were incubated at 37oC for 30 min in different concentration of NaCl and the extent of hemolysis was measured by colorimetry of the supernatant. Hemolysis percent was expressed in term of percent hemolusis in presense of distilled water (100% hemolysis).
Results: In this study although hemoglobin, haematocrit, mean corpuscular hemoglobin and mean corpuscular volume in group III were significantly (P<0.05) higher compared to group IV, the osmotic fragility did not show a significant difference.
Conclusion: The results indicate that hyperthyroidism in rat’s canno anemia and osmotic fragility of RBCs in hyperthyroid animals is not different from control groups.

 
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