Paper Information

Title: 

THE EFFECT OF L-CARNITINE ON MOUSE DAILY SPERM PRODUCTION AND EPIDIDYMAL SPERM PARAMETERS

Type: POSTER
Author(s): ZARE Z.*,MOHAMMADI MOSLEM,IMANI H.,FAGHIHZADEH S.
 
 *DEPARTMENT OF ANATOMY, BAQIYATALLAH UNIVERSITY OF MEDICAL SCIENCE, TEHRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: The objective of this study was to detect the effect of L-Carnitine(LC) on testicular spermatid number per gram testis (TSN), daily sperm production (DSP), count, motility, viability, morphology, and chromatine quality of epididymal sperm.
Methods: In the present study with exposure duration 2 weeks, male NMRI (mean aged 4-6 weeks),were doused with LC by gavage daily. The control group didn't receive LC. Experimental groups received 1mg LC/100µl diionized water and 10 mg LC/100µl diionized water. Sperm analysis was evaluated the end of this time. Sperm morphology was assessed using papanicula staining. Sperm chromatine quality also was evaluated using aniline- blue staining. After detached capsule testis, the paranchyme was homogenized. Homogenization resistant spermatid heads were counted by a improved neubouer haemocytometer. Number of spermatid was expressed as TSN. DSP was calculated by dividing the total number of spermatid per gram testis by 4.84.
Results: Administration of LC induced reduction of TSN, DSP, sperm count, and percentage of motility compared to control group, but there wasn't seen significant difference. Experiment grops had significantly increased in sperm chromatine quality (p<0.05). LC also increased normal morphology and viability, but there wasn't significant difference.
Conclusion: The results of this study demonstrated that LC administration seem to be ineffective in spermatogenesis of normospermic animals.

 
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