Paper Information

Title: 

EFFECT OF HYDROALCOHOLIC EXTRACT OF VACCINIUM ARCOSTAPHILOS ON BLOOD TRIGLYCERIDE, GLUCOSE ON MALE RAT AND STUDY OF PANCREATIC MICROSCOPY

Type: POSTER
Author(s): DEHGHANI F.,PANJEH SHAHIN M.R.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Diabetes mellitus is a chronic metabolic metabolic disease that has a significant impact for the researches. Today's peoples tendency to traditional medicine Vaccinum arctostaphilos (VAT) that been used as treatment for diabetes. The present study was antidiabetic and hypolipidemc activities of hydroalcoholic extract of VAT. For this purpose 46 rats were divided 6 groups. 4 groups received 250, 500, 1000, 1500 mg/kg of extract. Control and diabetic groups received water. Blood sampling take from caudal vein after 28 days then animals were scarified, pancreas removed, fixed with formalin 10% and stained with H&E. The results showed that in all doses significant reduction in triglyceride and glucose but not on cholesterol in blood. Histological experiment showed that in all groups, destruction of B-cells was accured and the extract didn't have healing effect on pancreatic tissue. According to experiment, hydroalcoholic extract of VAT have effect on reduction of blood glucose and triglyceride but no effect on B-cell. Although there should be more investigation regarding to clarify the exact mechanism.

 
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