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Paper Information

Title: 

COMPARISON OF TESTOSTERONE INJECTION IN RIGHT AND LEFT CA1 OF RATS ON SPATIAL LEARNING AND MEMORY

Type: POSTER
Author(s): BOZORGMEHR T.*,NAGHDI N.
 
 *DEP. OF PHYSIOLOGY AND PHARMACOLOGY, PASTEUR INSTITUTE OF IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: In most mammals, the hippocampus has a well documented role in spatial learning and memory. High concentration of androgen receptors exist in fundamental centers of learning and memory, such as hippocampus shown that there may be some relationship between androgen receptors and   cognitive aspect. Previous studies, have shown differences in morphology and physiology of the right and left hemisphere. This asymmetry in each hemisphere may be cause different responses so, this study designed to assess the effect of spatial learning and memory on its amount in left and right hippocampus of adult male rats.
Methods: Adult male rats were divided into 8 groups. 4 groups were cannulated in right CA1 and the others in left. Different groups were received   testosterone (0, 20, 40, 80 µg/0.5µl) 30 minute each day, before training by Morris water maze.
Results: Our results have revealed that injection of testosterone (80 µg /0.5µl) in left CA1 can significantly increase escape latency and travel distance in compare with control group.
Conclusion: These results may be shown that spatial learning in left CA1 were affected more by testosterone in compare with right CA1.

 
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