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Paper Information

Title: 

EXPERIMENTAL STUDY OF EFFECTS OF BUSPIRONE HCL ON PITUITARY-GONAD AXIS,HISTOLOGICAL CHANGES OF TESTIS & SPERMATOGENESIS PROCESS IN MALE RATS.

Type: POSTER
Author(s): JAFARPOUR H.*
 
 *ISLAMIC AZAD UNIVERSITY OF KAZEROON
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: This research with attenuated on spermatogenesis process and its relation with pituitary-gonad axis studied effects of Buspirone HCL on this subjects.
Material and Methods; The numbers of 40 adults male ra from wistar strain with 250±2gr weight which were divided to 5 group of 8.Treated groups received 10/20/40mg/kg B.w. of drug via intrperitonial method, daily, sham group received distilled-water as solvent and control group received anything. After 28th daily injection and in 29th day blood sample was obtained from heart and concentration of LH, FSH and testosterone was measured by RIA. In Addition the testes were separated and histological changes of testis was compared among experimental and control groups. The result evaluated by using ANOVA, DUNCAN, TUKEY and T-test (P≤0.05).
Results: The results show that concentration of LH and FSH in experimental groups didn’t show significant difference in compared with control group, but a significant decrease showed in concentration of testosterone in comparison with control group. In addition buspirone hcl had no effects on numbers and arrangements of spermatogona, primary permatosist, spermatids & spermatozoa cells.
Conclusion: We suggest that buspirone hcl, maybe are effectiveness by inhibition or stimulation of secretion of pituitary hormones like Dopamine & Prolaktin or Serotonine or by effect on receptors on testis cells can decreased testosterone volume in 28 days.

 
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