Paper Information

Title:  INVOLVEMENT OF CENTRAL MINERALOCORTICOID RECEPTORS IN GLUCOCORTICOID -INDUCED DEFICITS IN SPATIAL MEMORY RETRIEVAL IN RATS
Type: POSTER
Author(s): KHAKSARI M.*,RASHIDIPOUR A.,VAFAEI A.A.,ROSTAMZADEH F.
 
 *LABORATORY OF LEARNING AND MEMORY, DEPARTMENT AND RESEARCH CENTER OF PHYSIOLOGY, SEMNAN UNIVERSITY OF MEDICAL SCIENCES, SEMNAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Previous studies have indicated that stress levels of glucocorticoid hormones induce impairment of long term memory retrieval, but the underlying mechanisms (genomic or non-genomic) are not clear. To clarify this issue, we investigated the involvement of brain corticosteroid receptors and protein synthesis in the glucocorticoid-induced impairment of memory retrieval. Young rats were trained in a MWM task with six trials per day for six consecutive days. Retention of the spatial training was assessed 24 h after the last training session with a 60-s probe trial. Experiments included intraventricular injections of anisomycin as an inhibitor of protein synthesis or specific antagonists for the both types of corticocosteroid receptors before corticosterone administration at the time of retention testing. The results showed that administration of anisomycin did not change the corticosterone response. Administration of a type I, mineralocorticoid, but not type II glucocorticoid, receptor antagonist blocked corticosterone-induced response. These findings provide evidence for the view that glucocorticoids impair memory retrieval through non-genomic mechanisms involving an interaction with central type I mineralocorticoid receptors.

 
Keyword(s): 
 
Yearly Visit 8  
 
Latest on Blog
Enter SID Blog