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Paper Information

Title: 

EFFECTS OF INTRA-HIPPOCAMPAL INJECTION OF KAPPA OPIOID RECEPTOR AGONIST ON GLUCOCORTICOID-INDUCED IMPAIRMENT OF SPATIAL MEMORY RETRIEVAL IN RATS

Type: POSTER
Author(s): ROSTAMZADEH F.*,VAFAEI A.A.,RASHIDIPOUR A.,KHAKSARI M.
 
 *LABORATORY OF LEARNING AND MEMORY, PHYSIOLOGY DEPARTMENT AND RESEARCH CENTER, SEMNAN UNIVERSITY OF MEDICAL SCIENCES, SEMNAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Previous studies indicated that intra-hippocampal injections of Naltrexone as a classic antagonist of opioid receptor blocked glucocorticoid-induced deficit in memory retrieval, but the sort of opioid receptor of such an interaction were not known. The present study examined whether the kappa opioid receptors in the hippocampus interact with glucocorticoid effects on memory retrieval in a water maze (WM). 80 young rats (250-300gr) carrying bilateral cannulae aimed at the hippocampus were trained in a WM task with six trials per day for six consecutive days. Retention of the spatial training was assessed 24h after the last training session with a 60-s probe trial. Corticosterone (1mg/kg) was injected 30min before retention testing with or without prior bilateral intra-hippocampal injections of U111 (0.8, 2, 5 μg/0.5 µl per site) as a kappa opioid receptor agonist. The results show that corticosterone-induced impairment of memory retrieval was enhanced by intra-hippocampal infusions of U111 in a dose-dependent manner. These findings provide evidence for the view that glucocorticoids interact with the hippocampal kappa opioid receptors in influencing long-term memory retrieval.

 
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