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Paper Information

Title: 

ROLE OF CANNABINOID SYSTEM IN THE DORSAL HIPPOCAMPUS OF THE RATS IN THE MODULATION OF ANXIETY-LIKE BEHAVIORS USING ELEVATED PLUS-MAZE

Type: POSTER
Author(s): ROUHBAKHSH A.*,HAJIZADEH MOGHADAM A.,ALAH TAVAKOLI M.,POURSHANAZARI A.A.,REZVANI M.E.
 
 *DEPARTMENT OF PHYSIOLOGY AND PHARMACOLOGY, SCHOOL OF MEDICINE, RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES, RAFSANJAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Many studies have been conducted to determine the mechanisms underlying the modulation of anxiety but the role of some neurotransmitters such as cannabinoids in the modulation of anxiety have not been yet clarified. Moreover, brain regions which are involved in the behavioral effects of cannabinoids are unknown. In this study we put cannula bilaterally in the dorsal hippocampus (CA1 region) of the rats using stereotaxic surgery. 3 groups of rats received different doses (1, 2.5 and 5 µg/rat) of WIN55212-2 (a non-selective CB1 and CB2 agonist), 3 other groups received different doses (2, 10 and 50ng/rat) of AM251 (a selective CB1 receptor antagonist) and 3 groups received different doses of WIN55212-2 (1, 2.5 and 5 µg/rat) while they have been pretreated with 2ng/rat of AM251. Anxiety-like behaviors in rats were evaluated using elevated plus-maze test. In this method different parameters such as %OAT, %OAE and locomotor activity were videotaped. Our obtained results showed that WIN55212-2 and AM251 could decrease and increase %OAT and %OAE respectively without any locomotor impairment. This implies that injection of cannabinoid agoist induced anxiogenic effects while injection of cannabinoid antagonist induced anxiolytic effects in our experiment. Moreover, the results showed that injection of AM251 could reverse the anxiogenic effects of WIN55212-2 showing the importance of CB1 receptors in the anxiogenic effect of cannabinoids in the dorsal hippocampus of the rats.

 
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