Paper Information

Title:  NTERMITTENT AND PROLONGED NORMOBARIC HYPEROXIA REDUCE NEUROLOGIC DEFICIT SCORES AND INFARCT VOLUME CAUSED BY RAT BRAIN STROKE MODEL
Type: POSTER
Author(s): RAHNAMA M.*,BIGDELI M.R.,HAJIZADEH S.
 
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Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Ischemic tolerance (IT) is one of the important endogenous mechanisms responsible for increase of tolerance of brain tissue against brain damage after stroke. Despite considerable attempts on production of IT induced by the various sublethal stimulations, the clinical use of these methods is hardly acceptable because of their toxicity. In the other hand, no appropriate therapeutic dose of IT induced by normobaric hyperoxia (NBHO) is available yet. In this study, we examined the intermittent and prolonged dose of NBHO on brain damage volume and neurobehavioral deficits after middle cerebral artery occlusion (MCAO).
Material and Methods: The rats were exposed with NBHO in prolonged and intermittent groups. After 24 h, they were subjected to 60 minutes MCAO followed by 24h of reperfusion. Then, IT induced by intermittent and prolonged NBHO were assessed by infarct volume and neurologic deficit scores.
Results:  Our findings indicate that intermittent and prolonged NBHO are involved in the induction of IT. Pretreatment with prolonged reduce infarct volume by 63%, whereas intermittent NBHO decreased infarct volume by 82%. Neurologic deficit score reduced significantly in intermittent and prolonged NBHO.
Conclusion: Although further studies are needed to clarify the mechanisms of IT, intermittent NBNO not only is acceptable for clinical use because of low toxicity, but also it has stronger effect than prolonged NBHO on IT induction.   

 
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