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Paper Information

Title: 

EFFECT OF CORIANDER ON LEARNING AND MEMORY CONSOLIDATION IN BREAST-FEEDING MICE

Type: POSTER
Author(s): ZARGARNATAJ SEYED SADEGH,ZANGOURI VAHID,ZAKER ABBASI M.,MOGHADAMNIA A.A.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Coriander (Coriandrum sativum) had been suggested as sedative and anxiolytic agent in traditional medicine. This study was designed to investigate the effect of coriander extract on learning and memory consolidation in breast-feeding mice.
Methods: first of all, pregnant mice were selected. First day after delivery the mothers were injected 200mg/kg coriander extract in oil base. The dose was repeated every five day interval for totally five doses. All nursing mice were allowed to free feeding of milk in that period. After getting a suitable body weight of the mice, for learning test the step-through passive avoidance learning method was recruited. The mice were trained with three different shock periods (duration: 2, 4 and 8 second, 0.1 mA). Recall test was done 1hr, 24 hr and one week after training and cut-off time was considered maximum 300 seconds.
Results: in one hour after shock at three shock periods, saline improved recall more than coriander (P<0.001)but the results of recall at 24 hour and after one week of shock represented better recall for coriander. There was a better recall for coriander group in shock period 4 second in comparison to the other periods (P<0.01).
Conclusion: According to the data, it seems that coriander possibly can exert an amnesic effect only at one hour after shock but in the other periods it may improve recall time compared with saline.

 
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