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Paper Information

Title: 

EFFECT OF PIPERINE ON LEARNING AND MEMORY CONSOLIDATION IN BREAST-FEEDING MICE

Type: POSTER
Author(s): ZANGOURI VAHID,ZARGARNATAJ SEYED SADEGH,ZAKER ABBASIAN M.,MOGHADAMNIA A.A.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Up to date some central effects of piperine (an alkaloid of black pepper) have been reported. This study was designed to investigate the effect of piperine on learning and memory consolidation in breast-feeding mice.
Methods: first of all, pregnant mice were selected. First day after delivery the mothers were injected 100mg/kg piperine in oil base. The dose was repeated every five day interval for totally five doses. All nursing mice were allowed to free feeding of milk in that period. After getting a suitable body weight of the mice, for learning test the step-through passive avoidance learning method was recruited. The mice were trained with three different shock periods (duration: 2, 4 and 8 second, 0.1mA). Recall test was done 1hr, 24 hr and one week after training and cut-off time was considered maximum 300 seconds.
Results: At three shock periods, piperine improved recall more than saline. The mice receiving piperine at shock 2 second showed better recall than saline (p=0.02). There were a significant improvement in recall of piperine group at 24 hour (p=0.035) and one week (p=0.022) after shock of 4 second. This improvement was seen one week after shock period 8 second with piperine compared with saline (p=0.002).
Conclusion: According to the data, it seems that piperine may improve recall time in comparison to saline.

 
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