Paper Information

Title: 

ASSESSMENT OF ANALGESIC EFFECTS OF VERAPAMIL,DILTIAZEM & NIMODIPINE IN RAT; ROLE OF HYPOTHALAMO PITUITARY-ADRENAL AXIS

Type: POSTER
Author(s): DOULATSHAHI S.M.*,MOTAMEDI F.,ESMAEILI MAHANI SAEID
 
 *DEPARTMENT OF PHYSIOLOGY, NEUROSCIENCE REASERCH CENTER, SHAHEED BEHESHTI UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Controvertial reports indicating the analgesic effect of some L-type calcium channel blockers. But the involvement of Hypothalamo-Pituitary-Adrenal (HPA) axis is a matter of debate. In the present study possible analgesic effect of three L-type calcium channel blockers from different pharmacologic groups (Verapamil, Diltiazem & Nimodipine) and possible role of HPA axis on this effect have been evaluated.
Methods: The tail flick test was used to assess the effects of Verapamil, Diltiazem & Nimodipine on thermal pain threshold before and 15, 30, 60, 90 & 120 min after i.p. injection of these drugs to intact, sham & adrenalectomised (ADX) male wistar rats and for identification of interaction between these drugs and HPA function, plasma corticosterone level was measured by the Radioimmunoassay (RIA).
Results: In intact and sham operated rats administration of Verapamil & Diltiazem could not induce analgesia but in ADX rats exhibited a weak analgesia. Whereas, Nimodipine in all groups could induce an analgesic effect in ADX rats this effect was potentiated that can be reversed by corticosterone replacement.
Conclusion: Verapamil & Diltiazem (from two different types of Calcium channel blockers) do not have a significant analgesic effect in the tail flick test but Nimodipine has significant effect that can be potentiated by HPA disturbance (adrenalectomy) which is reversed by corticosterone replacement indicating involvement of HPA axis in this phenomenon.

 
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