Paper Information

Title: 

STUDY OF THE EFFECTS OF MATERNAL HYPOTHYROIDISM AND THYROXIN THERAPY ON THE NEURONAL DENSITY OF SUBICULUM IN RAT NEWBORNS

Type: PAPER
Author(s): DELSHAD Z.,BEHNAM RASOULI MORTEZA,FAZEL A.R.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: It is well established that thyroid hormones are essential for normal development of mammalian brain. Thyroid hormone deficiency during critical periods of brain development can have devastative and irreversible effects on neurological function, known as critinism. Maternal hypothyroidism causes reproductive problems for mothers including increased abortion and resorption, stillbirth and reduced litter size and newborns weight.
methods: Twenty five adult female Wistar rats were divided into three groups; experimental groups 1 and 2 and control. The experimental group 1 made hypothyroid by chemical thyroidectomy (500 mg/l PTU in drinking water). The experimental group 2 received levothyroxin as well (1mg/l in drinking water). The controls only received drinking water.
Results: The results are showing the abortion, resorption, stillbirth and decreased litter size and newborns' weight of experimental group 1. The results also indicate significant increased of neuronal density (Nv) of the subiculum in experimental group 1 than control (p<0.0004). Moreover there is a significant difference in Nv (p<0.0005) between experimental groups 1 and 2.
Conclusion: In addition to the effects of maternal hypothyroidism on the increase of abortion and resorption of fetuses, decrease of the newborns' brain size and weight and increase of their death, maternal hypothyroidism causes increased neuronal density of subiculum. It seems that thyroxin therapy can improve the effects of maternal hypothyroidism.

 
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