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Paper Information

Title: 

INVESTIGATION OF EFFECT OF SILYBUM MARIANUM (MILK THISTLE) ON PASSIVE AVOIDANCE LEARNING IN WISTAR RATS

Type: POSTER
Author(s): DARAB M.,PARIVAR KAZEM,YAGHMAEI PARICHEHR
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Silybum marianum (Milk thistle) has been used in treatment of liver disease for years. Much more research must be performed in order to determine of its clinical effects. Also reports have shown different results on the role of Milk thistle in differentiation and surviva of nerval cell. We tasted effect of Silybum marianum (Milk thistle) on learning and memory in wistar Rats. Pregent rats receive Silybum marianum from day 1 of pregency up to 4 weeks after birth orally (90 mg/kg and 180 mg/kg). The effect of drug on the learning and memory were assessed by a passive avoidance technique using shattle box apparatus. The result suggests that Silybum marianum is adose dependent component and increase learning and memory. Also it may act as an antioxidative agent by increasing NGF and main tenance of hippocampus neurons.

 
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