Paper Information

Title: 

THE EFFECT OF TESTOSTERONE AND FLUTAMIDE ON SPATIAL LEARNING AND MEMORY IN DENTATE GYRUS IN ADULT MALE RATS

Type: PAPER
Author(s): KHALILI DARMANI M.*,NAGHDI N.,KERAMATI K.,VAEZI GH.H.,BOZORGMEHR T.
 
 *DEPARTMENT OF PHYSIOLOGY & PHARMACOLOGY, PASTURE INSTITUTE OF IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Dentate gyrus is a part of the hippocampal formation that it has an important role in spatial learning and memory .it has been show that testosterone and its metabolites have an important role in spatial learning and memory. Also it has been reported that there is more density of androgen receptors in CA1, dentate gyrus and other area in hippocampal formation. In this study we investigated the effect of testosterone (an agonist of androgen receptor) and flutamide (a non steroid antagonist of androgen receptors) in DG area in spatial learning and memory.
Methods: 64 adult male rats were divided in 8 groups (control, Testosterone, flutamide).bilateral guide canulae were implanted in DG (AP-3.8  / ML±2.2 / DV-3.2) .then DMSO as solvent (control group ) , Testosterone enanthate (20,40, 80 µg/0.5 µl) and flutamide (1,2.5.10 µg/0.5 µl) were injected into DG. All injections were done 30 min before training and then trained in MWM task was done. The training session was 4 days and every day one block and every block 4 trials.
Results: The results have shown 80 µg/0.5 µl Testosterone and also 2 µg/0.5 µl flutamide could increase escape latency and traveled distance as compared control group but there was no significant difference in swim speed.
Conclusion: Our findings have shown that Testosterone and Flutamide injected in DG impaired spatial learning and memory. 

 
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