Paper Information

Title:  ANTI-NEUTROPHIL CYTOPLASMIC ANTIBODIES (ANTI-PR3, ANTI-TPO) IN PATIENTS WITH PULMONARY TUBERCULOSIS
Type: PAPER
Author(s): SHERKAT R.*,MOSTAFAVIZADEH K.,ZEYDABADI L.,SHOAEI P.
 
 *ISFAHAN UNIVERSITY OF MEDICAL SCIENCES
 
Name of Seminar: BIENNIAL CONGRESS ON IMMUNOLOGY, ASTHMA AND ALLERGY
Type of Seminar:  CONGRESS
Sponsor:  IRAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES
Date:  2007Volume 6
 
 
Abstract: 

Background: Mycobacterial tuberculosis is a major cause of mortality and morbidity worldwide. Infection with this bacterium is known to induce the development of autoantibodies and a few of these antibodies are also known to be diagnostic markers for some other diseases. ANCA’S are one of autoantibodies used in clinical setting for diagnosing systemic vasculitic syndrome. More than 20 studies investigating ANCA positivity in diseases other than small vessel vasculitis. This study was undertaken to determine the prevalence of ANCA in pulmonary tuberculosis which could lead to false diagnosis of Wegner’s granulomatosis or vice versa.
Material and Method: In a case-control study 32 consecutive smear positive pulmonary TB patients and 32 normal individuals were studied. All cases and controls screened for ANCA by indirect immunoflurecent (IIF) and also MPO and PR3 were tested by ELISA.
Results: Perinuclear pattern (P-NACA) was detected in 25% of cases and 6.25% of controls and cytoplasmic pattern (C-NACA) in 3.1% of both cases and controls by IIF assay. ANCA specificities by ELISA in cases revealed that 75% had anti-myleperoxidase and 12.5% had anti-Proteinase 3. In controls 3.12% had anti-MPO and no person had anti – PR3. The positive ANCA significantly correlated with tuberculosis (p value<0.018) and also positive MPO significantly correlated with TB. (p value<0.01)
Conclusion: Autoantibodies especially ANCA’S may present in both diseases (Wegner Granulomatosis and Tuberculosis). The presence of autoantibodies in TB patient could have a multifactorial etiology. The presence of human T lymphocytes reactive to heat stress proteins may be an important target of immune response against certain intracellular auto-antigens such as MPO from PMN added to the mechanism of molecular mimicry would explain the association of ANCA and TB.

 
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