Paper Information

Title: 

EFFECTS OF TIME AND DETERIOATION ON BRAIN ACETYLCHOLINESTERASE ACTIVITY OF BRAIN IN UNOPENED HEAD OF CATTLE

Type: SPEECH
Author(s): SALAR AMOLI J.*,MOUSAVI SHAMSI ALSADAT,ALI ESFAHANI T.
 
 *DEPARTMENT OF PHYSIOLOGY, PHARMACOLOGY AND TOXICOLOGY, VETERINARY FACULTY OF TEHRAN UNIVERSITY
 
Name of Seminar: IRANIAN CONGRESS OF TOXICOLOGY
Type of Seminar:  CONGRESS
Sponsor:  SOCIETY OF TOXICOLOGY
Date:  2004Volume 8
 
 
Abstract: 

The measurement of acetyl cholinesterase activity is one the most effective methods in diagnosis of poisoning with OP and OC insecticides. The usage of this method isn’t still recommended in Iran, besides that the submission of the samples is delayed or dead bodies are found after a period of time. So this research focused on the enzyme activity in the brain and to find out the effect of time and deteroation on its activity in cattle which has the most exposure to kind of insecticides. For this reason, 60 head of cattle collected from the slaughter houses around Tehran vicinity and kept in ambient environment, then autopsied in 3 continue days and the activity of brain acetyl cholinesterase measured with Ellman procedures. The average of enzyme activity was 3.39, 3.16 and 2.48ug\min\g in 1st, 2nd and 3rd day respectively. Also the clinical observation revealed that the brain was deteriorated two days after death. According to SPSS software the enzyme activity has decreasing trend during these days and the differences was significant (P<0.05) in 3rd day. Generally the results revealed that the activity of enzyme in brain is reliable until 48 hours of death but in the case of deteroation this method is not recommended.

 
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