Paper Information

Title: 

SURVEY THE SEROPREVALENCE OF HTLV I /II IN HEMODIALYSIS PATIENTS AND BLOOD DONORS IN URMIA

Type: PAPER
Author(s): ROSTAMZADEH KHAMENEH Z.*,BARADARAN SAFA M.,SEPEHRVAND N.,GHODRAT GHARAH BAGH Z.
 
 *URMIA UNIVERSITY OF MEDICAL SCIENCES
 
Name of Seminar: BIENNIAL CONGRESS ON IMMUNOLOGY, ASTHMA AND ALLERGY
Type of Seminar:  CONGRESS
Sponsor:  IRAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES
Date:  2007Volume 6
 
 
Abstract: 

Background: Human T lymphocyte Virus (HTLV) is a virus from retroviridae family which is presented as the cause of T cell leukemia, Spastic Paraparesis and tissue Necrotizing lymphadenitis. It is mainly transmitted by contaminated blood products, blood recipients such as Thalassemia, Hemophilia or Hemodialysis patients are at a high risk of infection to this virus. However, immunodeficiency in hemodialysis patients increases this risk. The aim of this study is to survey the seroprevalence of HTLV in hemodialysis patients and blood donors, and to analyze the effectiveness of each risk factor.
Material & Methods: In this Descriptive cross-sectional study, first data was collected about demographic features such as age, sex and the frequency of blood transfusion through a year in hemodialysis patients and blood donors (as control group) of Urmia, Iran in 2006. Blood serum was evaluated serologically in both of two groups by enzyme-linked immunosorbent assay (ELISA) for HTLV I /II and finally all collected data was analyzed by descriptive and chi-square tests by means of SPSS software ver11.5.
Results: 114 hemodialysis patients and 2046 blood donors was evaluated and there were 65 men (57%) and 49 women (42.9%) in hemodialysis group. Also there were 1910 (93.4%) men and 136 women (6.6%) among healthy blood donors.
Mean age of hemodialysis patients was 45 years old. 3 persons of 114 hemodialysis patients were seropositive for HTLV (prevalence of 2.63%), which two of them were female and one was male. Among all blood donors, 1997 persons (97.6%) were seronegative for HTLV and 49 persons (2.4%) were seropositive in ELISA serologic laboratory test and positive cases was confirmed by western blot. Finally in this group, total seroprevalence of HTLV was calculated 0.34%.
Discussion: Because we do not perform blood products screening in our region, blood recipients are at a high risk of HTLV infection. More transfusion times and immunodeficiency in hemodialysis patients has increased HTLV incidence in this group. So screening for HTLV in high risk groups suggested in this study.

 
Keyword(s): HTLV, HEMODIALYSIS PATIENTS, BLOOD DONORS
 
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