IMPORTANCE OF SHIP2 GENE IN OBESITY INDUCED MUSCLE INSULIN RESISTANCE: FOCUS ON PALMITATE

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GORGANI FIRUZJAEE SATTAR; AHMADI SAEEDEH; MESHKANI REZA

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Seminar Paper

Paper Information

Seminar: CONGRESS ON QUALITY IMPROVEMENT IN CLINICAL LABORATORIES
Year:2014 | Issue:12

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Title

IMPORTANCE OF SHIP2 GENE IN OBESITY INDUCED MUSCLE INSULIN RESISTANCE: FOCUS ON PALMITATE

Author(s)

GORGANI FIRUZJAEE SATTAR | AHMADI SAEEDEH | MESHKANI REZA | Issue Writer Certificate

Keywords

MUSCLE

INSULIN RESISTANCE

PALMITATE

SHIP2

Abstract

T2DM IS A HIGH PREVALENCE DISEASE AND OBESITY AND INSULIN RESISTANCE ARE MAIN RISK FACTORS IN PATHOGENESIS OF T2DM BUT THE EXACT MOLECULAR MECHANISM IS NOTE WELL UNDERSTOOD. MUSCLE INSULIN RESISTANCE HAS KEY ROLE IN WHOLE BODY GLUCOSE HOMEOSTASIS, ALMOST 80% OF INSULIN-DEPENDENT GLUCOSE UPTAKE IN THE BODY OCCURS IN THIS TISSUE. FAT ACCUMULATION IN MUSCLE CAUSES MUSCLE INSULIN RESISTANCE, IN THIS STUDY WE FOCUS ON THE EFFECT OF PALMITATE AS COMMON FREE FATTY ACID IN OBESE INDIVIDUAL CIRCULATION ON SH2 CONTAINING INOSITOL PHOSPHATASES (SHIP2) WHICH NEGATIVELY REGULATE INSULIN SIGNALING. WE USE C2C12 MUSCLE CELL LINE. AFTER DIFFERENTIATION, MYOTUBES TREATED WITH 0.2 AND 0.5 MM BSA-COMPLEXED PALMITATE AND C2 CERAMIDE 50MM FOR 16 H. SHIP2 EXPRESSION QUANTIﬁED BY REAL-TIME PCR AND WESTERN BLOT.0.5 MM PALMITATE AND 50 MM C2 CERAMIDE SIGNIFICANTLY INDUCED SHIP2 GENE EXPRESSION (P<0.05) BUT 0.25 MM PALMITATE NOT SIGNIFICANTLY INDUCED.

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APA: Copy

GORGANI FIRUZJAEE, SATTAR, AHMADI, SAEEDEH, & MESHKANI, REZA. (2014). IMPORTANCE OF SHIP2 GENE IN OBESITY INDUCED MUSCLE INSULIN RESISTANCE: FOCUS ON PALMITATE. CONGRESS ON QUALITY IMPROVEMENT IN CLINICAL LABORATORIES (7TH INTERNATIONAL & 12 NATIONAL CONGRESS). SID. https://sid.ir/paper/921630/en

Vancouver: Copy

GORGANI FIRUZJAEE SATTAR, AHMADI SAEEDEH, MESHKANI REZA. IMPORTANCE OF SHIP2 GENE IN OBESITY INDUCED MUSCLE INSULIN RESISTANCE: FOCUS ON PALMITATE. 2014. Available from: https://sid.ir/paper/921630/en

IEEE: Copy

SATTAR GORGANI FIRUZJAEE, SAEEDEH AHMADI, and REZA MESHKANI, “IMPORTANCE OF SHIP2 GENE IN OBESITY INDUCED MUSCLE INSULIN RESISTANCE: FOCUS ON PALMITATE,” presented at the CONGRESS ON QUALITY IMPROVEMENT IN CLINICAL LABORATORIES (7TH INTERNATIONAL & 12 NATIONAL CONGRESS). 2014, [Online]. Available: https://sid.ir/paper/921630/en

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