Paper Information

Title: 

THE IMMUNOMODULATORY EFFECT OF MICRONUTRIENTS FROM FRUITS AND VEGETABLES ON AUTOIMMUNE THYROIDITIS WITH HYPOTHYROIDISM IN CHILDREN AND ADOLESCENTS,THE FIRST REPORT

Type: PAPER
Author(s): RANJBAR A.R.*
 
 *INSTITUTE OF INTERVENTIONAL ALLERGOLOGY AND IMMUNOLOGY, BONN, GERMANY
 
Name of Seminar: BIENNIAL CONGRESS ON IMMUNOLOGY, ASTHMA AND ALLERGY
Type of Seminar:  CONGRESS
Sponsor:  IRAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES
Date:  2007Volume 6
 
 
Abstract: 

INTRODUCTION: Autoimmune processes are marked by the formation of autoantibodies, chronic inflammatory processes, and clinical symptoms which are caused by restriction or loss of function of the corresponding organ. Autoimmune thyroiditis is the most common cause of acquired hypothyroidism. Genetic factors, environmental influences as well as oxidative stress play an essential role in the development of the illness. Reactive oxygen species (ROS) generated during various metabolic and biochemical reactions have multifarious effects that include oxidative damage to DNA leading to various human degenerative and autoimmune diseases. Since increasing amounts of circumstantial evidence within the last few years indicate that autoimmune diseases such as autoimmune thyroiditis are triggered by free radicals, antioxidants may well be considered for the prevention and supportive treatment of such illnesses. The best synergy between antioxidants in nature is found in plant foods, which are rich in micronutrients and phytochemicals. In order to objectify these connections we investigated the influence of micronutrients from fruit and vegetables in addition to standard therapy with L-thyroxine.
METHODS: We conducted a randomized, prospective controlled study in 26 patients (age 11-17 years) suffering from autoimmune thyroiditis with hypothyroidism. We divided the patients in 2 groups. Group A (n=14) was treated with L-thyroxine in addition to a encapsulated fruit and vegetable juice powdered concentrate (FVJC) orally. Group B (n=12) was treated only with L-thyroxine. We measured TSH, FT3, FT4, TPO-Ab, TG-Ab, TSH-receptor-Ab, CRP, Malondialdehyde (MDA), Fe, Ferritin, Se, Zi, Cu, and Vitamin D, and assessed all patients clinically before, during and after therapy.
RESULTS: In group A we observed clinically a statistically significant improvement of all symptoms (physical and mental performance, intolerance of cold, constipation, hair loss) measured by means of a visual analogue scale (VAS) 4 weeks after therapy , compared to the group B (p<0.01). Parallel to the clinical improvement we measured in group A a statistically significant reduction of TSH and MDA levels in blood (p<0.01) 8 weeks after therapy and a statistically significant decrease of TPO-Ab and TG-Ab 24 weeks after therapy, compared to group B (p<0.05).
CONCLUSION: For the first time we were able to show that this approach led to a reduction in oxidative stress (measured with MDA values), to a decrease in the autoantibodies TPO-Ab and TG-Ab, to lower TSH levels, and also to a clear improvement in the clinical symptoms. These results speak for a complex immunological and metabolic process which cannot be positively influenced by the substitution of exogenous thyroid hormones alone. It is definitely conceivable that the micronutrients not only modulate the immune system, but also support metabolism in those human cells which are damaged and destroyed by excessive formation of free radicals in this disease, and result in better utilisation of the thyroid hormones in the cell.

 
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