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Paper Information

Title: 

KINETICS OF CYTOMEGALOVIRUS (CMV)-SPECIFIC CD4 RESPONSE FOLLOWING ALLOGENEIC HEMATOPOIETIC STEM CELL (HSC) TRANSPLANTATION

Type: PAPER
Author(s): POURGHEYSARI B.,BRUTON R.,MOSS P.
 
 
 
Name of Seminar: BIENNIAL CONGRESS ON IMMUNOLOGY, ASTHMA AND ALLERGY
Type of Seminar:  CONGRESS
Sponsor:  IRAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES
Date:  2007Volume 6
 
 
Abstract: 

Introduction: CMV continues to be an important cause of mortality and morbidity in HSC recipients. CMV seropositivity has been identified as an important risk factor for the survival of both sibling and unrelated donor HSC recipients. The development of effective T cell immunity is important in the control of CMV infection and disease and depends on a clear understanding of immune reconstitution. There is increasing interest in the role of CD4+ T cells in developing an effective immunity against CMV.
Method: We studied CMV-specific CD4+ T cell reconstitution following allogeneic stem cell transplantation in a cohort of 32 patients at risk of CMV reactivation. Patients had been treated with a myloablative or non-myoablative conditioning regimen for hematological malignancies. CMV viremia was monitored by quantitative PCR. CMV-specific CD4 T cells were identified by intracellular cytokine staining before transplantation and every two weeks thereafter. CMV serology of recipient/donor was (+/+) in 53.1%, (+/-) in 34.4% and (-/+) in 12.5%.
Results: The reconstitution of CD4+ T cells in the post transplantation period is normally later than CD8+ T cells. Most patients with CMV reactivation had low frequency and number of CMV-specific cells at the time of reactivation and then had increases afterwards. The number of CMV-specific cells did not show such a sharp increase, because of stability of the CD4+T cells. Some patients had a reactivation when there were no detectable CMV-specific CD4+ T cells. The frequency of CMV-specific CD4+ T cells peaked when the viral load was not detectable anymore and then declined afterwards. The number of CMV-specific CD4+ T cells also changed as a variable, but the changes were not sharp and seemed to follow CD4+ T cells recovery.
Conclusion: The CMV reactivation seems to happen in the absence or low CMV-specific CD4 response, but a good recovery happens afterward.

 
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