Paper Information

Title: 

POLYPOSIS, ASTHMA AND EOSINOPHILS

Type: PAPER
Author(s): NARAGHI M.*,FARAJZADEH ARMIN
 
 *RHINOLOGY RESEARCH CENTER, OTORHINOLARYNGOLOGY RESEARCH CENTER, DIVISION OF RHINOLOGY, DEPARTMENT OF OTORHINOLARYNGOLOGY, HEAD AND NECK SURGERY, TEHRAN UNIVERSITY OF MEDICAL SCIENCES
 
Name of Seminar: BIENNIAL CONGRESS ON IMMUNOLOGY, ASTHMA AND ALLERGY
Type of Seminar:  CONGRESS
Sponsor:  IRAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES
Date:  2007Volume 6
 
 
Abstract: 

Background: Nasal polyposis (NP) is a chronic inflammatory disorder of the upper respiratory tract, which often coexists with asthma. Eosinophils which are found in large number in nasal polyps and asthmatic airways are considered to have a crucial role in pathogenesis of nasal polyps and asthma.
Objective: The aim of this retrospective study was to determine whether prevalence of asthma and serum eosinophilia in patients with nasal polyps is higher than control group (patients with no associated respiratory diseases).
Methods: 238 patients who had undergone nasal polyp surgery during a five-year period, were retrospectively studied (M=171, F=67, age range: 5-79 yr, mean age: 38 yr). The control group included 200 patients with cholesteatoma. Age and sex were matched in both groups. The diagnosis of asthma was based on a documented physician diagnosis. The other data such as nasal symptoms, intolerance to aspirin, previous polyp surgery and measuring serum eosinophilia were evaluated.
Results: In NP group 18.7% were asthmatic and 81.3% non asthmatic. (In comparison with control group, 4% were asthmatic and 96% non asthmatic).
Values of asthma and serum eosinophilia in NP patients were significantly higher (p=0.005 and p=0.045, respectively) than control group.
Conclusion: We have demonstrated a greater degree of asthma and serum eosinophilia in NP patients compared with control group. This would suggest that eosinophils may have a key role in pathogenesis of these diseases.

 
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