Paper Information

Title: 

INVESTIGATING THE INTERFERENCE OF NITRIC OXIDE AND ESTROGEN EFFECTS ON MEMORY AND LEARNING IN OVARIECTOMIZED WISTAR RATS

Type: POSTER
Author(s): HEYDARI RAHELEH*,ORYAN SHAHRBANOU,HOSSEINI SEYED MAHMOUD,SHARIF KHODAEI Z.
 
 *DEPARTMENT OF BIOLOGY, FACULTY OF SCIENCE TARBIAT MOALLEM , UNIVERSITY OF TEHRAN, TEHRAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Menopause is characterized with drastic decrease in serum estrogen. On average women, spend 1/3 of their lifespan at the menopause. Cognitive and memory impairments are frequently reported by women at menopause.
Increasing evidence suggest that estrogen receptors are involved in nonreproductive functions including variety of tasks requiring hippocampal spatial cognition. Some studies indicate estrogen treatment on young OVX rodents may enhance learning, spatial, and non-spatial memory. Contradictory reports consider crucial roles for estrogen in memory retention and learning, while others do not approve the same results.
Considering the remarkable interactions between some neurotransmitter systems, significantly nitric oxide and estrogen the interference of these two paths are investigated in the current study. 60 female wistar rats (160±10gr, with the age of 8 weeks) were enrolled in this study. Randomly half of them were ovariectomized and others went under same operation without removing ovaries. OVX and Sham rats have received daily injections (i.p) of L-NAME (the NOS inhibitor) and L-Arginine (the NOprecursor) along with weekly estradiol valerate injections (i.m) for 6 weeks. At the end of treatment period in order to evaluate memory function, rats went through Morris Water Maze test. The analysis of time latency, distance and speed show that Simultaneous treatment with LArginine and estradiol enhances the ability of memory retention more than mere administration of L-Arginine. Although increase of serum estrogen along with NO enhances the memory function but this effect strongly depends on specific doses of estrogen.

 
Keyword(s): ESTROGEN, MEMORY, NITRIC OXIDE
 
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