Paper Information

Title: 

EFFECT OF CHRONIC ADMINISTRATION OF CANNABINOIDS ON LONG AND SHORT TERM PLASTICITY IN HIPPOCAMPAL DENTATE GYRUS

Type: POSTER
Author(s): RONAGHI A.A.A.*,MOTAMEDI F.,NADERI NIMA
 
 *NEUROSCIENCE RESEARCH CENTER, SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

CB1 receptors are abundant in hippocampus. Where memory processing occurred? Cannabinoid (CB) effect on memory is a controversial issue. The aim of present study is to investigate the effect of chronic administration of CBs on long and short term plasticity in hippocampal dentate gyrus (DG).
By chronic (7days) introcerebroventricular injection of CB agonist (WIN55212- 2) and antagonist(AM251)with electrical stimulation of perforant pathway and recording from DG, the effect of these drugs on long term synaptic plasticity using LTP induction and short term plasticity using paired pulse index (PPI) were investigated in rats. Also by chronic (10) IP injection of indirect CB agonist (URB597) the effect of endocannabinoids were also tested.
WIN55212-2 (25mg) prevented LTP induction, while CB1 antagonist and endocannabinod agonist URB597 had no effect on LTP. WIN55212-2 significantly decreased PPI (10, 20, 30, 50ms intervals) comparing to the control group. On the other hand, URB597 decreased PPI in 30 and 50 ms intervals.
Chronic administration of cannabinoids decreases synaptic plasticity in DG in rats in vivo which results in memory deficiency.

 
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