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Paper Information

Title: 

SESAME OIL INJECTION INCREASED MEMORY IN THE FEMALE MICE

Type: POSTER
Author(s): MOHAMMADPOUR KARGAR HOSSEIN,AHMADI MANDANA,KESMATI MAHNAZ,FATHI MOGHADAM H.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Sesame oil is useful oil that contains large amount of unsaturated fatty acids and has application as agent for decreasing blood glucose and cholesterol or increasing milk. In his research effect of sesame oil injection (i.p.) on memory was studied.
Method: female mice (25±3g) were used. Animals divided to four groups: control and three test groups that injected 0.1 ml sesame oil (i.p.) for 1, 2 and 4 days respectively. Fear conditioning test carried out in three steps. 1- Animals take place in test compartment for 5 min in first day. 2- in second day, each animal exposed to noise for 3 min and finally received foot shock (5 sec, 5mA). 3-After 1 hour and 24 hour returned to same cage and freezing time was measured. All data was analyzed by one way ANOVA.
Results: There was not any significant difference between control and other groups in the test after 1 hour. There was significant difference in freezing time after 24 hour between control group and group that sesame oil was injected for 4 days (P<0.04).
Conclusion: It seems that sesame oil unsaturated fatty acids affect plasma membrane properties and affects ion channels conductivities or probably lecithin of sesame oil acts as a source for acetylcholine and potentate cholinergic system in brain specially amigdala. More studies need to determine facts.

 
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