Paper Information

Title: 

COMPARISON BETWEEN ANESTHETIZED AND NON-ANESTHETIZED RATS TREATED WITH SELECTIVE INOS INHIBITOR IN MORRIS WATER MAZE

Type: POSTER
Author(s): TABRIZIAN K.*,BELARAN M.,AZAMI K.,NAJAFI SH.,SHARIFZADEH MOHAMMAD
 
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Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Objects: nitric oxide (no) is thought to be involved in spatial learning and memory in several brain areas such as the hippocampus. This study examined the effects of post-training intrahippocampal infusion of 1400w as a selective inos inhibitor on spatial memory retention, in both anesthetized and non-anesthetized animals.
Materials and methods: in non-anesthetized animals, a guide canula was implanted into the ca1 area of the hippocampus for the infusion of 1400w into this area. In both groups (32 animals in each group), animals were treated with the deionized water and 1400w. Training trials were started after recovery of the canulated animals. Immediately after last trial of training on fourth day, the deionized water and 1400w (10, 50 and 100μm) were infused bilaterally and testing trials were performed 48 hours after drug infusions in both groups.
Results: significant reduction were observed in escape latency and traveled distance in canulated group after 1400w infusions (100μm/side, p<0.05). Also, there was a significant alteration between canulated and non-canulated rats that were received 1400w (100μm/side , p<0.001).
Conclusion: it is concluded that 1400w as an inos inhibitor improve dspatial memory retention in non-anesthetized animals. Results from the behavioral study need to be confirmed by immunohistochemical analyses in our future sudies.

 
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