Paper Information

Title: 

THE EFFECT OF ORAL AND INTRAPERITONEAL ADMINISTRATION OF ACORUS CALAMUS L. EXTRACT ON LEARNING AND MEMORY IN MALE RATS

Type: POSTER
Author(s): AZIZI YASER*,HEYDARI HAMID,KHALILI M.,KIASALARI Z.,SADEGHIAN AZAM
 
 *SCHOOL OF MEDICINE, SHAHED UNIVERSITY, TEHRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Objective: Regarding the role of memory in the human life and with respect to the factors which attenuated memory retention, the new strategies were recommended. For this purpose the new compounds active against brain neural degeneration could be necessary. There are many recommendations for herbal medicine, which encouraged us to examine the effect of a candidate plant Acorus calamus for improvement of memory.
Materials and Methods: Male NMRI rats (250-300 g) were divided to control and treatment groups. Treatment group consist of four subgroups including 1-oral, 2, 3 and 4 subgroups received the plant extract at doses of 25, 50 and 100 mg/kg; i.p. In order to investigate the spatial recognition, animals were conducted to Y maze experiment. The data acquisition - recalling (STL) which considered as the light-dark room pass time by using shuttle box test. The pscychomotor coordination trials were done ones by rota-road treadmill apparatus.
Results: STL time for oral (22.23 ± 0.8) and scalating injected doses groups (25, 50 and 100 mg/kg) were calculated 12.12±1.48, 16.16±1.48 and 19.15 ± 0.98 respectively. There is a significant difference between STL time in all treatment groups and control ones. The alternative behavior (%) extracted from Y maze test in oral group were marked (P<0.01) than control animals. Pscychomotor index times have shown no difference in any groups.
Conclusion: oral and intraperitoneal administration of the extract in higher dose could have increase spatial recognition and recalling the data, regarding to its low efficacy in changing pscychomotor index time.

 
Keyword(s): ACORUS CALAMUS L, LEARNING AND MEMORY, Y MAZE, PASSIVE AVOIDANCE, RAT
 
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