Paper Information

Title: 

EFFECT OF INTRAHIPPOCAMPAL INFUSION OF S100B PROTEIN ON LEARNING IN MALE RATS

Type: POSTER
Author(s): JAMALZADEH L.*,BABAEI PARVIN,KERAMATI KEYVAN
 
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Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Introduction: the calcium-binding protein s100b is predominantly expressed and secreted by astrocytes in vertebrate brain and plays important role in neural synaptic plasticity and information processing in the brain.
Purpose: in present study the effect of different doses of s100b,
were studied on learning for a passive avoidance task in rats.
Materials and methods: for this purpose, the rats divided into four experimental groups (5, 50, 500, or 5000ng s100b) and one control group (saline). Two weeks after recovery, animals were trained in a step-down passive avoidance task (1ma, 100hz, 5sec). Immediately after training, animals received a 0.5μl infusion of saline or s100b, and were tested 24 h later. Step-down first latency and total time spent on platform were measured as learning memory indices.

Results: the results showed that s100b protein, in doses of 5ng, increased learning (p<0.01), while in the doses of 500 and 5000ng impaired memory (p<0.001) for a passive avoidance task.
Conclusion: infusion of s100b into the ca1 region of hippocampus, dose depently modulates memory, thus in a low dose (nanogram), facilitates memory, while in high doses (microgram) impairs memory.

 
Keyword(s): S100B, HIPPOCAMPUS, PASSIVE AVOIDANCE LEARNING, MEMORY, RAT
 
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