Paper Information

Title: 

THE EFFECT OF LONG-TERM ADMINISTRATION OF CYANIDIN ON LEARNING AND MEMORY IN DIABETIC RATS

Type: POSTER
Author(s): NASRI SIMA,ROGHANI MEHRDAD,BALUCHNEJADMOJARAD TOURANDOKHT,BALVARDI M.*,RABANI T.
 
 *DEPARTMENT OF BIOLOGY, PAYAMNOUR UNIVERSITY, TEHRAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Background and Aim: Chronic diabetes mellitus accompanies disturbances in learning, memory, and cognitive skills. With regard to antidiabetic potential of cyanidin, the effect of its chronic administration on learning and memory in diabetic rats was investigated.
Materials and Methods: Male rats were divided into control, cyanidin-treated control, diabetic, and cyanidin-treated diabetic groups. For induction of diabetes, streptozotocin was injected i.p. at a single dose. Cyanidin was administered i.p. one other day 1 week after diabetes induction for two months. For evaluation of learning and memory, initial (IL) and step-through latencies (STL) were determined at the end of study using passive avoidance test and alternation behavior percentage was obtained using Y maze.
Results: STL significantly decreased in diabetic (p<0.01) and cyanidin-treated diabetic (p<0.01) group and the existing difference between these group was not statistically significant. Alternation percentage was significantly lower in diabetic group relative to control (p<0.01) and treated diabetic group showed a significantly higher alternation in comparison with diabetic group (p<0.05).
Conclusion: Although chronic treatment with cyanidin could not enhance the capability of consolidation and recall in diabetic animals, but could improve spatial memory in diabetic animals.

 
Keyword(s): CYANIDIN, LEARNING, MEMORY, DIABETES MELLITUS
 
Yearly Visit 12   tarjomyar
 
Latest on Blog
Enter SID Blog