Paper Information

Title: 

EFFECTS OF PRENATAL WIN 55212-2 EXPOSURE ON MOTOR AND LEARNING BEHAVIORS OF RAT OFFSPRING

Type: POSTER
Author(s): SHEYBANI VAHID,SHAABANI MOHAMMAD*,HAGHANI MASOUD,JANAHMADI MAHYAR
 
 *NEUROSCIENCE RESEARCH CENTER AND PHYSIOLOGY RESEARCH CENTER, KERMAN UNIVERSITY OF MEDICAL SCIENCES, KERMAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Introduction: Cannabis consumption during pregnancy may affect the development of fetal growth, motor performance, memory and cognitive functions.
Methods: Primiparous pregnant Wistar rats were randomly assigned to four treatment groups (six rats per group): control, Win treated groups were received daily 0.5 or 1mg/kg WIN suspended in 1% Tween 80 saline (s.c.) at a volume of 1 ml/kg and sham treated rats were given 1% Tween 80 saline from days 5 to 20 of pregnancy. Third, fifth and seventh weeks after birth, the effects of maternal Win consumption on infants body weight, mortality, memory function and motor performance were assessed. 2nd day after birth, righting responses in rat pups were also compared.
Results: Offspring from Win (1mg/kg) treated rats exhibited a significant loss in the righting reflex on the 2nd day after birth, when compared to other groups. However, there was no statistically significant difference between groups regarding motor coordination assessed using rotarod test on the 3rd and 5th weeks after birth. Passive avoidance learning (PAL) test showed that during the acquisition trials, approach latencies were not significantly different between all groups of rats (50 days old). However, when the trial was repeated 24h and seven days later (retention trial), the avoidance latencies of the Win-exposed group were significantly shorter than those of control and sham animals.
Conclusion: These findings suggest that prenatal exposure to Win, cannabinoid agonist, induces possibly a long-term alteration of the endocannabinoid system, which in turn affect learning and motor coordination ability.

 
Keyword(s): CANNABINOIDS, MATERNAL CONSUMPTION, MOTOR PERFORMANCE, MEMORY
 
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