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Paper Information

Title: 

INTERACTION OF LITHIUM CHLORIDE AND SCH ON STATEDEPENDENT MEMORY IN THE STEP-DOWN PASSIVE AVOIDANCE TEST

Type: POSTER
Author(s): SADAT SHIRAZI M.S.,SARAHROUDI SH.,MAHBOUBI S.H.,REZAEIAN SAREH,ZARINDAST M.R.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

The effects of Lithium chloride on state dependent memory of a passive avoidance task were examined in mice. Post-training intracerebroventricular administration of LiCl (0, 0.5, 1, 2, 4μg/mouse) in three different post-training times (0, 30, 45 min)led to state-dependent learning with impaired memory recall on the test day. The posttrain (15 min) intraperitoneal (ip) administration of SCH (0.025 mg/kg), a D1 dopamine receptor antagonist, with post-train (30min) intracerebroventricular administration of LiCl (0.25, 0.5, 1μg/mouse) didn’t show any interaction between SCH and Lithium. Although that post-train (30min) Administration of SCH alone (0.025 mg/kg) significantly impaired memory recall on the test day. In conclusion, the impairment of memory recall by Lithium chloride treatment, on the test day, seems to be through the destruction of inositole mono-phosphatase and inositole poly phosphatase that is haltered by Li. And also cause that there is no interaction between Li and SCH, so we can say that destruction of memory by Li isn’t dependent to dopaminergic system.

 
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