Paper Information

Title: 

BLOCKADE OF MINERALOCORTICOID AND GLUCOCORTICOID RECEPTORS IMPAIR MEMORY RECONSOLIDATION IN RATS

Type: POSTER
Author(s): NIKZAD S.,VAFAEI A.A.*,RASHIDIPOUR A.
 
 *LABORATORY OF LEARNING AND MEMORY, DEPARTMENT AND RESEARCH CENTER OF PHYSIOLOGY, SEMNAN UNIVERSITY OF MEDICAL SCIENCES, SEMNAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Previous studies have indicated that mineral corticoid receptors (MR) and glucocorticoids receptors (GR) enhance memory consolidation, but their effects onmemory reconsolidation are not clear. In this study, we studied the role of MR and GR on memory reconsolidation. 60 young rats were trained in a passive avoidance task. For memory reactivation, rats were returned to the chamber 48 h later. Immediately after reactivation, rats were injected with MR antagonist spironolactone (50 mg/kg) or GR antagonist RU38486 or spironolactone+RU38486. Control animals received vehicle. Two, four, and seven days after memory reactivation, rats were returned to the context for 10 min, and step-through latency was recorded.
The results showed that administration of spironolactone or RU38486 or combination of both induced impairment of memory reconsolidation.
Further, the results showed that drugs deficit was not reversed by a reminder shock. These findings provide evidence that blockade of glucocorticoid and mineral corticoid receptors impair memory reconsolidation.

 
Keyword(s): GLUCOCORTICOIDS RECEPTOR, MINERALOCORTICOID RECEPTOR, MEMORY RECONSOLIDATION, PASSIVE AVOIDANCE TASK
 
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