Paper Information

Title: 

SYSTEMIC ADMINISTRATION OF CORTICOSTERONE IMPAIRS RECONSOLIDATION OF AVOIDANCE MEMORY IN MI

Type: POSTER
Author(s): JAFARIAN Z.,VAFAEI A.A.,RASHIDIPOUR A.,HAJI SOLTANI R.*
 
 *LABORATORY OF LEARNING AND MEMORY, DEPARTMENT AND RESEARCH CENTER OF PHYSIOLOGY, SEMNAN UNIVERSITY OF MEDICAL SCIENCES, SEMNAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Introduction: Previous studies have indicated that glucocorticoids enhance memory consolidation, but their effects on memory reconsolidation are not clear. In this study, we studied the effects of corticosterone on memory reconsolidation in mice.
Material and Methods: 40 mice were trained in a passive avoidance task. For memory reactivation, mice were returned to the chamber 48 h later. Immediately after reactivation, mice were injected with corticosterone (0.3, 1 or 3 mg/kg) or vehicle. Two, five, seven and nine days after memory reactivation, rats were returned to the context for 10 min, and step-through latency was recorded.
Result: the result showed that corticosterone at dose of 3 mg/kg impairs memory reconsolidation. Further, the results showed that corticotserone deficit was not reversed by a reminder shock.
Conclusion: These findings indicate that post-reactivation administration of glucocorticoids impair memory reconsolidation.

 
Keyword(s): CORTICOSTERONE, RECONSOLIDATION MEMORY, MICE
 
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