Paper Information

Title: 

ROLE OF NMDA RECEPTORS OF BASOLATERAL AMYGDALA IN AMNESIA INDUCED BY INTRA-HIPPOCAMPAL INJECTION OF CANNABINOID RECEPTOR AGONIST WIN-55,212-2

Type: POSTER
Author(s): HABIBI P.,REZAYOF A.,ZARINDAST M.R.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Recent studies have revealed that endocannabinoids play an important role in cognitive functions. The hippocampus, which is an important site in learning and memory processes, expresses high levels of cannabinoid receptors. There is a functional interaction between hippocampus and the basolateral amygdala (BLA) during processing of a learning task. The current study was undertaken to determine the involvement of N-methyl-D-aspartate (NMDA) receptors of basolateral amygdala in amnesia induced by intra-hippocampal injection of cannabinoid receptor agonist WIN-55,212-2. A step-through type passive avoidance task was used in order to assessment of memory retrieval. Adult male Wistar rats were stereotaxically implanted with guide cannulas into the CA1 region and the BLA. Post-training microinjection of WIN 55, 212-2 (0.1-0.5μg/rat) a non-selective CB1/CB2 receptor agonist into the CA1 regions of dorsal hippocampus dose-dependently induced impairment of memory retrieval, indicating cannabinoid-induced amnesia. Post-training microinjection of D-AP5, a NMDA receptor antagonist (0.02-0.5μg/rat) 5 min before intra-CA1 microinjection of WIN 55, 212-2 (0.5μg/rat, intra-CA1) significantly reversed amnesia induced by intra-hippocampal injection of cannabinoid receptor agonist WIN-55,212-2. Post-training intra-BLA administration of the same doses of DAP5 plus intra-CA1 administration of saline (0.3μl/rat), alone did not affect memory retrieval. Taken together, our results suggest that the glutamategic system of the BLA is involved in mediating amnesia induced by intrahippocampal injection of cannabinoid receptor agonist.

 
Keyword(s): NMDA RECEPTOR, BASOLATERAL AMYGDALA, AMNESIA, D-AP5, WIN-55,212-2, CANNABINOID
 
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