Paper Information

Title: 

EFFECTS OF PERIPHERAL AND CENTRAL BETA-ADRENERGIC RECEPTORS BLOCKADE ON EXERCISE INDUCED ENHANCEMENT OF LEARNING AND MEMORY IN RAT

Type: POSTER
Author(s): EBRAHIMI KHANACHA SH.*,RASHIDIPOUR A.,VAFAEI A.A.,MOHAMMAD AKHAVAN M.
 
 *LABORATORY OF LEARNING AND MEMORY, DEPARTMENT AND RESEARCH CENTER OF PHYSIOLOGY, SCHOOL OF MEDICINE, SEMNAN UNIVERSITY OF MEDICAL SCIENCES, SEMNAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

The beneficial effects of physical activity and exercise on brain functions such as improvement in learning and memory are well documented. The aim of this study was to examine the role of peripheral and central beta adrenergic receptors in voluntary-exercise induced enhancement of learning and memory in rat. In order to block the peripheral and central beta adrenergic receptors, the animals were received the beta-antagonist propranolol (10 mg/kg), or the peripherally acting beta-antagonist nadolol (20 mg/kg) before each night of five consecutive nights of exercise, respectively. Then their learning and memory were tested on the Morris water maze (MWM) task using a two-trial-per-day for five consecutive days. A probe trial was performed two days after the last training day. Our results showed that propranolol, but not nadolol reversed the exercise induced improvement in learning and memory in rat. These findings indicate that central, but not peripheral beta-adrenergic receptors may mediate the effects of exercise on learning and memory.

 
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