Paper Information

Title: 

THE EFFECT OF INTRA HIPPOCAMPAL INJECTIONS OF DIHYDROTESTOSTERONE ON SPATIAL MEMORY IN INTACT MALE RAT

Type: POSTER
Author(s): BABRI SH.,GHOTBI R.,MOTAMEDI F.,NAGHDI N.,RAZAVI MOVAHED S.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Dihydrotestosterone (DHT) is an endogenous hormone that is derived from testosterone in an enzymatic reaction mediated by 5-alpha reductase. The high density of androgen receptors and 5-alpha reductase enzyme have been found in the centers of learning and memory in hippocampus ,and improvement in learning and memory followed by administration of DHT to gondectomized male rats indicates androgens role in learning and memory. Eighty male rats randomly divided into ten equal groups. Two Canules were implanted in CA1of animals in all groups except control. After 1 week the experiments were started. Control group tested in Morris Water Maze. One group received 0.5μl saline 30 min and two other groups received 0.5μl DMSO 30 min and 24 hour before tests intrahippocampaly. Doses of 5, 10 and 20 Microgram DHT were solved in 0.5μl DMSO and in three groups were injected in CA1 30 min before test and in the other three groups 24 hours before it. Our results showed that injection of DHT different doses 24hours before tests had no meaningful effects on learning and memory retrieval in Morris Water Maze but injection of 10μg of it, 30 min before tests decreased swimming path significantly (p<0.05) and increased traveled distance percent in target quadrant (p<0.05). Results showed that DHT in dose of 10 microgram could improve acquisition and retrieval in intact male rats.

 
Keyword(s): DIHYDROTESTOSTERONE, ACQUISITION, RETRIEVAL, 5-ALPHA REDUCTASE, MORRIS WATER MAZE
 
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