Paper Information

Title: 

INVOLVEMENT OF NMDA RECEPTORS IN THE VENTRAL TEGMENTAL AREA ON SCOPOLAMINE INDUCED AMNESIA IN MALE RATS

Type: POSTER
Author(s): MAHMOUDI G.*,ORYAN SHAHRBANOU,ZARINDAST M.R.,POURMOTABED ALI,REZAYOF A.
 
 *DEPARTMENT OF BIOLOGY, SCHOOL OF SCIENCE, SCIENCE AND RESEARCH INSTITUTE, ISLAMIC AZAD UNIVERSITY TEHRAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Ventral tegmental area (VTA) is a part of mesencephalon that has an important role in learning and memory. There are some reports about the importance of cholinergic and glutamatergic systems in memory processes. Therefore in the present study, the effect of NMDA receptors located in the VTA on the memory deficits induced by scopolamine was investigated. 2 cannulae were stereotaxically implanted bilaterally into VTA adult male rats (220-250), a step through passive avoidance task, as a model of learning and memory was used. After 1 week recovery animals received bilateral intra VTA injection of scopolamine (0.25 or 0.5 or 1 or 2or 3μg/rat), MK801 (0.5 or 0.75 or 1 or 1.5μg/rat), NMDA (0.001 or 0.01 or 0.1μg/rat) ,scopolamine (0.25,0.5μg/rat)+ MK801 (0.5μg/rat), scopolamine (2μg/rat)+ NMDA (0.001,.01μg/rat) after training and 24h later memory parameter was tested. Our results showed that Post-training intra-VTA microinjection of scopolamine (2,3μg/rat) and MK801 (1, 1.5μg/rat) impaired memory. Interestingly injection of ineffective doses of MK801 (0.5μg/rat) and scopolamine (0.25, 0.5μg/rat), (0.001, 0.01μg/rat) in combination with an effective dose of scopolamine (2μg/rat) prevented the impairing effect of scopolamine in memory. These results suggest a possible role of NMDA receptors located in the VTA on scopolamine induced memory impairment.

 
Keyword(s): SCOPOLAMINE, NMDA, MK801, VENTRAL TEGMENTAL AREA (VTA), MEMORY, RAT
 
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